The rainy days are coming but I know it is not too late to have a good post summer vacation. Boracay is the place to be. I surely enjoyed the Boracay sun, ambiance and leisure. Beside from the memorable experience, the fantastic island also gave me a take home gift –a big wound which I think will mark forever on my skin. I got it from an accident I got from riding an All Terrain Vehicle (ATV).
Way the go Boracay! Thanks for
this awesome souvenir!
Well everything happens for a reason and I can’t do anything about it now but help my body heal itself and guard it from any invading infection . Aside from taking antibiotics, I was given a tetanus shot and I was advised to clean this “remembrance” every day with some hydrogen peroxide and iodine. I was instructed to remove pus that was formed. Believe me it hurts like crazy.
That wasn’t the only trouble I have to encounter. Every day I walk limping because of the pain I feel from my wound. It is a real hassle. Sometimes I experience a mild fever probably because of infection.
This is why I salute the guy who discovered ACETAMINOPHEN. Does it ring a bell? It is commonly called Paracetamol in the Philippines. This drug is an analgesic and anti-pyretic which means bye bye pain and bye bye fever.
Honestly, I haven’t experienced any form of toxicity from a drug so let me just tell you some facts. Acetaminophen is probably one of the most used drugs. It is an over the counter drug so anyone can have unlimited access over it. The use of acetaminophen is safe but of course anything that is in excess is a BIG NO NO! The recommended dose for acetaminophen is 4 grams every 24 hours. Anything more than this (usually more than 10-15 grams per day) may cause liver toxicity. Because of this the patient may develop acid buildup in the blood, excessive
bleeding, and coma.
The most common effect of acetaminophen overdose is liver toxicity. In the liver, acetaminophen is excreted through the hepatic mixed-function oxidase system. If the normal processing system is besieged by a high dose,a different pathway known as the cytochrome P450 enzyme system dribbles in. When this happens, a toxic metabolic byproduct called NAPQI (N-acetyl-p-benzoquinone imine) is produced that can kill liver cells.
Luckily, the ever popular antioxidant, Glutathione, is naturally produced in the body to neutralize NAPQI. But if the glutathione is used up, an amino acid called N-acetylcysteine (NAC), is administered to restore glutathione and reverse acetaminophen toxicity.
Check "ME"out for more info of acetaminophen poisoning
Anything else I need to know? - FACTS and WARNINGS
Serum indicators for hepatocyte damage do not become abnormal until 3-5 days after ingestion of toxic dose.
Do not take acetaminophen for more than 10 days in a row.
People who do consume 2-3 alcoholic drinks per day should not take more than half the usual recommended dose of acetaminophen.
People with advanced liver fibrosis or cirrhosis should avoid acetaminophen.
High performance liquid chromatography, competitive enzyme and immunoassay techniques are the most common method to quantify acetaminophen in the serum.
Clinchem30b fact # 4
Always remember to follow your doctor’s prescription and never ever overdose a drug. Be sure to read the medication label and if possible write down how much drug you take. All drugs when taken in high dosage may induce toxic effects. INGAT! THANKS FOR READING!
references:
M. Bishop; Clinical Chemistry: Principles, Procedures, Correlations
http://www.hcvadvocate.org/hepatitis/factsheets_pdf/Acetominophen.pdf
http://www.merck.com/mmpe/sec21/ch326/ch326c.html
http://www.thetoyzone.com/2009/blog/33-most-deadly-substances-on-earth/
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